課程名稱 |
生物無機化學 Bio-inorganic Chemistry |
開課學期 |
99-2 |
授課對象 |
理學院 化學所化學生物學組 |
授課教師 |
張啟光 |
課號 |
Chem5026 |
課程識別碼 |
223 U0840 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期二5,6(12:20~14:10)星期四7,8(14:20~16:20) |
上課地點 |
化121化121 |
備註 |
本課程中文授課,使用英文教科書。外系所學生選修需經授課教師同意。上課日期:4/25-6/17。 限學士班三年級以上 且 限本系所學生(含輔系、雙修生) 總人數上限:60人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/992Chem5026 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course examines the structures, reactivity and functions of metal ions in biological systems. This field of research is interdisciplinary, connecting inorganic chemistry to biochemistry, biology, biophysics, pharmacology, and toxicology
The course will contain selections of the following topics:
The coordination chemistry of metal ions and bioinorganic model systems.
Introduction to the techniques used for studying metal ions in biological systems.
The coordination chemistry of biological dioxygen transport.
Dioxygen activating iron enzymes such as heme containing cytochrome P450, Nonheme mononuclear iron and di-iron enzymes.
Dioxygen activating copper enzymes (monooxygenases, multi-copper oxidases). Other enzymes in oxygen metabolism such as superoxide dismutase, peroxidases and catalase.
Nickel-, cobalt-, molybdenum-containing enzymes and models
Nitrogenase and biological dinitrogen fixation and nitra(i)te reductions
Metalloproteins in biological electron transfer (photosynthesis, respiration and redox enzymes) and the physical nature of electron transfer
Metal ion complexes’ interaction with nucleic acids.
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課程目標 |
The tentative schedule of lectures:
Week 1: Introduction of metalloenzyme; chelating and coordinating ligands
Week 2: Techniques and spectroscopies
Week 3: O2 transport; hemoglobin/myoglobin, hemerythrin, hemocyanin
Week 4: O2 activation; oxygenases (P450, MMO); peroxidase/catalase; SOD
Week 5: Electron transfer; multielectron redox centers; cytochrome oxidase
Week 6: Nickel-, cobalt-, molybdenum-containing enzymes and models
Week 7: Nitrogenase; photosynthetic reaction centers, (Pt anticancer drugs)
Week 8: Metal toxicity and therapeutic applications
Week 9: Exam/student presentations
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課程要求 |
Grade will be based on exam and presentation/participation.
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第10週 |
4/26 |
Intro. |
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