課程資訊
課程名稱
 健康與疾病之護理處置
Nursing Intervention to Health and Illness 
開課學期
 112-2 
授課對象
 醫學院  護理學研究所  
授課教師
 蔡劭瑜 
課號
 NURSE8030 
課程識別碼
 426ED4440 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期三8,9(15:30~17:20) 
上課地點
 護智能教室 
備註
 本課程以英語授課。與羅美芳合授
限博士班
總人數上限：20人 
  
課程簡介影片
 
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課程大綱
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課程概述

This course addresses the current theories and research in the study of nursing therapeutics. We describe the implications of nursing therapeutics on research design and clinical practice and examine the practice of nursing to promote, maintain and restore human health. 

課程目標
 1.Articulate the nature, conceptual bases and scope of nursing therapeutics.
2.Explore the evidence synthesis of specific nursing interventions in theoretical basis, methodology, measurements and findings.
3.Identify issues related to the empirical knowledge relating to the effectiveness of nursing therapeutics.
4.Develop the perspectives on the development of the science of nursing therapeutics. 
課程要求
 1. Manuscript review and response
2. Term paper
3. Class participation 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 Books:
Hulley, S. B., Cummings, S. R., Browner, W. S., Grady, D., & Newman, T. B. (2013). Designing clinical research (4th ed.). Lippincott Williams & Wilkins.
*Nelson, H. D. (2014). Systematic reviews to answer health care questions (1st ed.). Lippincott Williams & Wilkins. (electronic book）
Piantadosi, S. (2017). Clinical trials: A methodologic perspectives (3rd ed.). John Wiley & Sons.
*Sidani, S., & Braden, C. J. (1998). Evaluating nursing intervention: A theory-driven approach. Sage.

Journal Articles:
*Muka, T., Glisic, M., Milic, J., Verhoog, S, Bohlius, J., Bramer, W., Chowdhury, R., & Franco, O. H. (2020). A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. European Journal of Epidemiology, 35, 49-60.
*Mun, Z., Peters, M. D., Stern, C., Tufanaru, G., McArthur, A., & Aromataris, E. (2018). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Medical Research Methodology, 18(1), 1-7
*Taylor, J., & Bradbury-Jones, C. (2014). Writing a helpful journal review: Application of the 6 C’s. Journal of Clinical Nursing, 23, 2695-2697.
*Yuan, Y., & Hunt, R. H. (2009). Systematic reviews: The good, the bad, and the ugly. The American Journal of Gastroenterology, 104(5), 1086-1092.

1. Conceptual basis of nursing therapeutics
Curtis, K., Fry, M., Shaban, R. Z., & Considine, J. (2017). Translating research findings to clinical nursing practice. Journal of Clinical Nursing, 26(5-6), 862-872.
Fawcett, J., Watson, J., Neuman, B., Walker, P. H., & Fitzpatrick, J. J. (2001). On nursing theories and evidence. Journal of Nursing Scholarship, 33(2), 115-119. (required)
Jordan, Z., Lockwood, C., Munn, Z., & Aromataris, E. (2019). The updated Joanna Briggs institute model of evidence-based healthcare. International Journal of Evidence-Based Healthcare, 17(1), 58-71.
Mackey, A., & Bassendowski, S. (2017). The history of evidence-based practice in nursing education and practice. Journal of Professional Nursing, 33(1), 51-55. (required)
Porter, S. (2010). Fundamental patterns of knowing in nursing: The challenge of evidence-based practice. Advances in Nursing Science, 33(1), 3-14. (required)
Sidani, S., Doran, D. M. & Mitchell, P. H. (2004). A theory-driven approach to evaluating quality of nursing care. Journal of Nursing Scholarship, 36(1), 60-65. (required)
Smith, M. C., Chinn, P. L., & Nicoll, L. H. (2021). Knowledge for Nursing Practice: Beyond Evidence Alone. Research and Theory for Nursing Practice, 35(1), 7–23. (required)
2. Randomized clinical trials (Ⅰ)
Equator Network: Enhancing the Quality and Transparency Of health Research http://www.equator-network.org/
Armstrong, R., Waters, E., Moore, L., Riggs, E., Cuervo, L. G., Lumbiganon, P., & Hawe, P. (2008). Improving the reporting of public health intervention research: advancing TREND and CONSORT. Journal of Public Health, 30(1), 103-109. (required)
Clark, L., Fairhurst, C. & Torgerson, D.J. (2016). Allocation concealment in randomized controlled trials: Are we getting better? BMJ, 355, i5663. (required)
Djulbegovic, B., & Guyatt, G. H. (2017). Progress in evidence-based medicine: A quarter century on. Lancet, 390(10092), 415-423. (required)
Huwiler-Muntener, K., Juni, P., Junker, C., & Egger, M. (2002). Quality of reporting of randomized trials as a measure of methodologic quality. Journal of the American Medical Association, 287(21), 2801-2804. (required)
Liu, X., Rivera, S. C., Moher, D., Calvert, M. J., Denniston, A. K; SPIRIT-AI and CONSORT-AI Working Group. (2020). Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: The CONSORT-AI Extension. BMJ, 370, m3164. doi: 10.1136/bmj.m3164.
Murad, M. H., Asin, N., Alsawas, M. & Alahdab, F. (2016). New evidence pyramid. BMJ Evidence-Based Medicine, 21(4), 125-127.
Schulz, K. F., Altman, D. G., Moher, D. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials. Annals of Internal Medicine, 152(11), 1-8.
3. Randomized clinical trials (Ⅱ)
Armijo-Olivo, S., Warren, S., & Magee, D. (2009). Intention to treat analysis, compliance, drop-outs and how to deal with missing data in clinical research: A review. Physical Therapy Review, 14(1), 36-49. (required)
Granholm, A., Alhazzani, W., Derde, L. P. G., Angus, D. C., Zampieri, F. G., Hammond, N. E.,… Møller, M. H. (2022). Randomised clinical trials in critical care: Past, present and future. Intensive Care Medicine, 48(2), 164-178.
Heritire, S. R., Gebski, B. J., & Keech, A. C. (2003). Inclusion of patients in clinical trials analysis: The intention-to-treat principle. Medical Journal of Australia, 179, 438-440. (required)
Little, R. J., D'Agostino, R., Cohen, M. L., Dickersin, K., Emerson, S. S., Farrar, J. T., ... & Stern, H. (2012). The prevention and treatment of missing data in clinical trials. New England Journal of Medicine, 367(14), 1355-1360.
Polit, D. F., & Gillespie, B. M. (2010). Intention-to-treat in randomized controlled trials: Recommendations for a total trial strategy. Research in Nursing & Health, 33, 355-368. (required)
Thabane, L., Mbuagbaw, L., Zhang, S., Samaan, Z., Marcucci, M., Ye, C. , … Goldsmith, C. H. (2013). A tutorial on sensitivity analyses in clinical trials: The what, why, when and how. BMC Medical Research Methodology, 13, 92. doi: 10.1186/1471-2288-13-92. (required)

4. Issues in conducting intervention research: Setting, intervener and client
Axén, I., Björk Brämberg, E., Galaasen Bakken, A., & Kwak, L. (2021). Recruiting in intervention studies: Challenges and solutions. BMJ Open, 11(1), e044702.
Gadke, D. L., Kratochwill, T. R., & Gettinger, M. (2021). Incorporating feasibility protocols in intervention research. Journal of School Psychology, 84, 1–18. (required)
Kotz, D., & West, R. (2022). Key concepts in clinical epidemiology: Addressing and reporting sources of bias in randomized controlled trials. Journal of Clinical Epidemiology, 143, 197-201. (required)
Langer, S. L., Castro, F. G., Chen, A. C., Davis, K. C., Joseph, R. P., Kim, W. S., Larkey, L., Lee, R. E., Petrov, M. E., Reifsnider, E., Youngstedt, S. D., & Shaibi, G. Q. (2021). Recruitment and retention of underrepresented and vulnerable populations to research. Public Health Nursing, 38(6), 1102–1115.
Mody, L., Miller, D. K., McGloin, J. M., Freeman, M., Marcantonio, E. R., Magaziner, J., & Studenski, S. (2008). Recruitment and retention of older adults in aging research. Journal of the American Geriatrics Society, 56, 2340-2348.
Sidani, S., & Braden, C. J. (2001). Evaluating nursing interventions: A theory driven approach (Chap. 4 Characteristics of clients, pp. 63-86). Sage.（book chapter, required）
Sidani, S., & Braden, C. J. (2001). Evaluating nursing interventions: A theory driven approach (Chap. 5 Intervener and setting characteristics, 87-104). Sage.（book chapter, required）
Tramm, R., Daws, K., & Schadewaldt, V. (2013). Clinical trial recruitment-A complex intervention? Journal of Clinical Nursing, 22, 2436-2443. (required)

5. Issues in conducting intervention research: Content and design
Brandt, P. A., Kirsch, S. D., Lewis, F. M., & Casey, S. M. (2004). Assessing the strength and integrity of an intervention. Oncology Nursing Forum, 31(4), 833-837. (required)
Clark, A., Breitenstein, S., Martsolf, D. S.., & Winstanley, E. L. (2016). Assessing fidelity of a community-based opioid overdose prevention program: Modification on the fidelity checklist. Journal of Nursing Scholarship, 48(4), 371-377.
Conn, V. S., Rantz, M. J., Wipke-Tevis, D. D., & Maas, M. L. (2001). Designing effective nursing interventions. Research in Nursing & Health, 24(5), 433-442. (required)
Crane, R. S., & Hecht, F. M. (2018). Intervention integrity in mindfulness-based research. Mindfulness, 9, 1370- 1380 https://doi.org/10.1007/s12671-018-0886-3
Ioannidis, J. P. A., Munafo`, M. R., Fusar-Poli, P., Nosek, B. A. & David, S. P. (2014). Publication and other reporting biases in cognitive sciences: Detection, prevalence, and prevention. Trends in Cognitive Sciences, 18(5), 235-241.
Sidani, S., & Braden, C. J. (2001). Evaluating nursing interventions: A theory driven approach (Chap. 6 Intervention variables, pp. 105-137). Sage. (book chapter, required）
Viols, C. I., King, H. A., Maciejewski, M. L., Allen, K. D., Yancy Jr, W. S., & Shaffer, J. A. (2014). Approaches for informing optimal dose of behavioral interventions. Annals of Behavioral Medicine, 48(3), 392-401. (required)
6. Issues in conducting intervention research: Analysis and outcome
Boeije, H. R., Drabble, S. J., & O'Cathain, A. (2015). Methodological challenges of mixed methods intervention evaluations. Methodology: European Journal of Research Methods for the Behavioral and Social Sciences, 11(4), 119-125. (required)
Chen, L., Huang, L. H., Xing, M. Y., Feng, Z. X., Shao, L. W., Zhang, M. Y., & Shao, R. Y. (2016). Using the Delphi method to develop nursing-sensitive quality indicators for the NICU. Journal of Clinical Nursing, 26, 502-513.
Clarke, G. M., Conti, S., Wolters, A. T., & Steventon, A. (2019). Evaluating the impact of healthcare interventions using routine data. British Medical Journal, 365, l2239. (required)
Fleischman, R. J., Adams, A. L., Hedges, J. R., Ma, O. J., Mullins, R. J., & Newgard, C. D. (2010). The optimum follow-up period for assessing mortality outcomes in injured older adults. Journal of the American Geriatrics Society, 58(10), 1843-1849.
O’Connell, B. O., & Warelow, P. J. (2001). Challenges of measuring and linking patient outcomes to nursing interventions in acute care settings. Nursing and Health Sciences, 3, 113-117. (required)
Sidani, S., & Braden, C. J. (2001). Evaluating nursing interventions: A theory driven approach (Chap. 7 Outcomes-related factors, pp. 138-169). Sage.（book chapter, required）
7. Alternative approaches to study therapeutics
Fischer, F. H., Lewith, G., Witt, C. M., Linde, K., von Ammon, K., Cardini, F.,…Brinkhaus, B. (2014). High prevalence but limited evidence in complementary and alternative medicine: Guidelines for future research. BMC Complementary and Alternative Medicine, 14, 46. doi: 10.1186/1472-6882-14-46. (required)
Mason, S., Torey, P., & Long, A. F. (2002). Evaluating complementary medicine: Methodological challenges of randomized controlled trials. British Medicine Journal, 325(7368), 832-834. (required)
Sikorskii, A., Wyatt, G., Victorson, D., Faulkner, G., & Rahbar, M. H. (2009). Methodological issues in trials of complementary and alternative medicine interventions. Nursing Research, 58(6), 444-451. (required)
Truant, T. L., Balneaves, L. G., & Fitch, M. I. (2015). Integrating complementary and alternative medicine into cancer care: Canadian oncology nurses’ perspectives. Asia Pacific Journal of Oncology Nursing, 2, 205-214.
Ventola, C. L. (2010). Current issues regarding complementary and alternative medicine (CAM) in the United States. Pharmacology & Therapeutics, 35(8), 461-468.
White, A., Boon, H., Alraek, T., Lewith, G., Liu, J. P., Norheim, A. J., Steinsbekk, A., Yamashita, H., & Fonnebo, V. (2014) Reducing the risk of complementary and alternative medicine (CAM): Challenges and priorities. European Journal of Integrative Medicine, 6, 404-408.
Wyatt, G., Sikorskii, A., Rahbar, M. H., Victorson, D., Adams, L. (2010). Intervention fidelity: Aspects of complementary and alternative medicine research. Cancer Nursing, 33(5), 331-42. doi: 10.1097/NCC.0b013e3181d0b4b7. (required)

8. Meta-analysis and using of research findings in clinical decision
Aromataris, E., Fernandez, R., Godfrey, C. M., Holly, C., Khalil, H., & Tungpunkom, P. (2015). Summarizing systematic reviews: Methodological development, conduct and reporting of an umbrella review approach. International Journal of Evidence-Based Healthcare, 13(3), 132-140. (required)
Bello, A., Wiebe, N., Garg, A., & Tonelli, M. (2015). Evidence-based decision-making: Systematic reviews and meta-analysis. In P.S., Parfrey & B. J., Barrett (eds.), Clinical epidemiology: Practice and methods. Methods in Molecular Biology, vol. 1281, DOI 10.1007/978-1-4939-2428-8_24. Springer. (required)
Fusar-Poli, P., Radua, J. (2018). Ten simple rules for conducting umbrella reviews. Evidence Based Mental Health, 21(3), 95-100.
Ioannidis, J. P. A., Munafo`, M. R., Fusar-Poli, P., Nosek, B. A. & David, S. P. (2014). Publication and other reporting biases in cognitive sciences: Detection, prevalence, and prevention. Trends in Cognitive Sciences, 18(5), 235-241.
Moore, Z. (2012). Meta-analysis in context. Journal of Clinical Nursing, 21(19-20), 2798-2807.
Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2018). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Medical Research Methodology, 18,143. https://doi.org/10.1186/s12874-018-0611-x.
Murad, M. H., Montori, V. M., Ioannidis, J. P. A., Jaeschke, R., Devereaux, P. J., Prasad, K., …Guyatt, G. (2014). How to read a systematic review and meta-analysis and apply the results to patient care. JAMA, 312(2), 171-179. (required)
Page, M. J. et al. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. British Medical Journal, 372, n71 doi: 10.1136/bmj.n71
Shuldham, C., Fleming, S., & Yorke, J. (2008). Undertaking a systematic review: The road to successful completion. Journal of Research in Nursing, 13(4), 282-298.

9. Review and critique of state of science of clinical therapeutics: Redefine the nursing therapeutics
Conn, V. S., Ruppar, T. M., Phillips, L. J., Chase, J. A. D. (2012). Using meta-analysis for comparative effectiveness research. Nursing Outlook, 60(4), 182-190.
Fawaz, M. (2021). Role of nurses in precision health. Nursing Outlook, 69(6), 937-940. (required)
Fu, M. R. et al. (2020). Precision health: A nursing perspective. International Journal of Nursing Sciences, 7, 5-12. (required)
Goss, C. H., & Feffe, N. (2013). Comparative effectiveness research-What is it and how does one do it? Paediatric Respiratory Reviews, 14, 152-156. (required)
Hasting-Tolsma, M., Matthews, E. E., Nelson, J. M., & Schmiege, S. (2013). Comparative effectiveness research: Nursing science and health care delivery. Western Journal of Nursing Research, 35(6), 683-702. (required)
Hickey, K. T. et al. (2019). Precision health: Advancing symptom and self-management science. Nursing Outlook, 67, 462-475. (required)
Ielapi, N., Andreucci, M., Licastro, N., Faga, T., Grande, R., Buffone, G., Mellace, S., Sapienza, P., & Serra, R. (2020). Precision medicine and precision nursing: The era of biomarkers and precision health. International Journal of General Medicine,13, 1705-1711.
Neely, J. G., Sharon, J. D., Graboyes, E. M., Paniello, R. C., Nussenbaum, B., Grindler, D. J., & Dassopoulos, T. (2013). Practical guide to understanding comparative effectiveness research (CER). Otolaryngology-Head and Neck Surgery, 149(6), 804-812.
Schaumberg, D. A., McDonald, L., Shah, S., Stokes, M., Nordstrom, B. L., & Ramagopalan, S. V. (2018). Evaluation of comparative effectiveness research: A practical tool. Journal of Comparative Effectiveness Research, 7(5), 503-515.
Yuan, C. (2015). Precision nursing: New era of cancer care. Cancer Nursing, 38(5), 333-334.
 
評量方式
(僅供參考)
    
課程進度
週次
日期
單元主題
第1週
 2/21  15:30-17:20 Introduction to the course Tsai, Lou 
第2週
 2/28  Holiday 
第3週
 3/06  15:30-17:20 1.Conceptual basis of nursing therapeutics Tsai 
第4週
 3/13  15:30-17:20 2. Randomized clinical trials (I) Tsai 
第5週
 3/20  15:30-17:20 3. Randomized clinical trials (II) Tsai 
第6週
 3/27  15:30-17:20 Discussion of term paper (I) Topic selection Tsai 
第7週
 4/03  15:30-17:20 4. Issues in conducting intervention research I: Setting, intervener and client Tsai 
第8週
 4/10  15:30-17:20 5. Issues in conducting intervention research II: Content and design Lou 
第9週
 4/17  15:30-17:20 6. Issues in conducting intervention research III: Analysis and outcome Lou 
第10週
 4/24  15:30-17:20 7. Alternative approaches to study therapeutics Lou 
第11週
 5/01  15:30-17:20 Discussion of term paper (II) Concept integration Lou 
第12週
 5/08  15:30-17:20 8. Meta-analysis and using of research findings in clinical decision. (Term paper to reviewer) Lou 
第13週
 5/15  15:30-17:20 9. Review and critique of state of science of clinical therapeutics: Redefine the nursing therapeutics. (Reviewer comments returned) Lou 
第14週
 5/22  15:30-17:20 Term paper presentation (5 students) Tsai, Lou 
第15週
 5/29  15:30-17:20 Term paper presentation (5 students) Tsai, Lou 
第16週
 6/5  15:30-17:20 Course evaluation Tsai, Lou