Course Information
Course title
 光學診斷技術
OPTICAL TECHNIQUES IN DIAGNOSIS 
Semester
 96-2 
Designated for
 COLLEGE OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCE  GRADUATE INSTITUTE OF BIOMEDICAL ELECTRONICS AND BIOINFORNATICS  
Instructor
 宋孔彬 
Curriculum Number
 BEBI7004 
Curriculum Identity Number
 945 M2900 
Class
  
Credits
 3 
Full/Half
Yr.
 Half 
Required/
Elective
 Elective 
Time
 Thursday 2,3,4(9:10~12:10) 
Room
 明達203 
Remarks
 The upper limit of the number of students: 24. 
Ceiba Web Server
 http://ceiba.ntu.edu.tw/962Opt_Diagnosis 
Course introduction video
 
Table of Core Capabilities and Curriculum Planning
 Table of Core Capabilities and Curriculum Planning
Course Syllabus
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Course Description

使用光學方法可以達到非侵入式的量測，這點在醫學的診斷上尤其重要。本課程將介紹使用各種光譜技術，擷取與人體組織的生理與病理特性相關的資訊，進而達到協助醫學診斷(特別是癌症前期病變)的目的。 

Course Objective
 1.教授光在組織中傳遞的理論模型。
2.使學生熟悉Monte Carlo法，以數值模擬光在組織中的傳播。
3.使學生瞭解各種光譜技術的基本原理，以及達成疾病診斷的工作原理。
 
Course Requirement
 學生需具備使用電腦軟體(例如C,Matlab)進行數值模擬的能力 
Student Workload (expected study time outside of class per week)
  
Office Hours
 Mon. 13:00~14:00
Tue. 11:00~12:00 
Designated reading
  
References
 1. "Optical-Thermal Response of Laser-irradiated Tissue", edited by Ashley J.
Welch and Martin J.C. van Gemert. New York: Plenum Press, 1995.
2. "Biomedical Photonics Handbook", edited by Tuan Vo-Dinh. Boca Raton, Fla.:
CRC Press, 2003.
3. "Biomedical Optics: Principles and Imaging", by Lihong V. Wang and Hsin-i Wu.
Wiley-Interscience, 2007. 
Grading
  
No.
Item
%
Explanations for the conditions
1. 
 作業 
50% 
 Monte Carlo法，模擬光在組織中的傳遞 
2. 
 期末專題計畫書 
10% 
 專題題目、動機、重要性以及相關文獻探討 
3. 
 期末專題 
40% 
 利用作業所完成之數值模擬工具，應用於光學診斷系統之參數模擬與效能最佳化。 
 
Progress
Week
Date
Topic
第1週
 02/21  Introduction 
第2週
 02/28  Holiday 
第3週
 03/06  Definitions and overview of tissue optics 
第4週
 03/13  Monte Carlo simulation #1: Absorption, scattering, and propagation of photons in tissue 
第5週
 03/20  Diffusion Theory of Light Transport #1 
第6週
 03/27  Diffusion Theory of Light Transport #1 
第7週
 04/03  Monte Carlo simulation #2: Grid structure and finite beams 
第8週
 04/10  Monte Carlo simulation #2 
第9週
 04/17  Monte Carlo simulation #3: 1.Multi-layer tissue model. 2. Propagation of fluorescent light 
第10週
 04/24  Monte Carlo simulation #4: Use detectors to detect remitted photons. 
第11週
 05/01  Diffusion Theory of Light Transport #2 
第12週
 05/08  Optical diagnostic methods: overview and light scattering spectroscopy 
第13週
 05/15  Diffuse reflectance spectroscopy 
第14週
 05/22  Fiber-optic probe geometry in reflectance spectroscopy 
第15週
 05/29  Polarized light reflectance spectroscopy 
第16週
 06/05  Monte Carlo in inverse models of diffuse reflectance spectroscopy 
第17週
 06/12  Project proposal presentation and discussion